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American Society of Microbiology ABMM Sample Questions:

1. A patient develops a severe diarrheal illness after consuming raw seafood. Stool culture yields a Gram- negative, comma-shaped bacterium that is oxidase-positive and grows on thiosulfate-citrate-bile salts-sucrose (TCBS) agar, producing blue-green colonies. The MOST significant virulence factor contributing to the severe, cholera-like diarrhea caused by this organism is:

A) Cholera toxin (CT)-like enterotoxin
B) Heat-labile toxin (LT)
C) Type III secretion system (T3SS)
D) Heat-stable enterotoxin (ST)

2. A patient develops a severe skin and soft tissue infection following a boating accident in the Gulf Coast.
Wound cultures grow a Gram-negative, halophilic bacterium that is oxidase-positive. The MOST likely organism is:

A) Pseudomonas aeruginosa
B) Aeromonas hydrophila
C) Vibrio vulnificus
D) Shewanella putrefaciens

3. A microbiology laboratory receives a CSF sample from a patient with suspected fungal meningitis. India ink staining reveals encapsulated yeast cells. Culture on Sabouraud dextrose agar grows creamy white colonies.
The MOST likely organism is:

A) Mucor species
B) Aspergillus flavus
C) Cryptococcus neoformans
D) Candida albicans

4. Vancomycin resistance in Enterococcus faecium, mediated by the vanA gene cluster, results from:

A) Decreased outer membrane permeability to vancomycin
B) Enzymatic inactivation of vancomycin by phosphorylation
C) Efflux pump overexpression removing vancomycin from the cell
D) Modification of the drug target from D-alanyl-D-alanine to D-alanyl-D-lactate

5. A patient presents with a pruritic rash consisting of raised, serpiginous tracks on their skin. The patient recently returned from a Caribbean vacation and reported walking barefoot on the beach. The MOST likely causative organism is:

A) Larvae of Ancylostoma braziliense
B) Pediculus humanus
C) Sarcoptes scabiei
D) Larvae of Strongyloides stercoralis

Solutions: